Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis
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چکیده
منابع مشابه
Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.
A number of factors have been identified that increase the risk of hepatocellular carcinoma (HCC). Recently it has become appreciated that type II diabetes increases the risk of developing HCC. This represents a patient population that can be identified and targeted for cancer prevention. The biguanide metformin is a first-line therapy for the treatment of type II diabetes in which it exerts it...
متن کاملMetformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice.
The prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is increasing with the growing epidemics of obesity and diabetes. NAFLD encompasses a clinicopathologic spectrum of disease ranging from isolated hepatic steatosis to NASH, which is a more aggressive form of fatty liver disease, to cirrhosis and, finally, hepatocellular carcinoma (HCC). The exact ...
متن کاملced Lung Tumorigenesis
r Prev Res vation of the mammalian target of rapamycin (mTOR) pathway is an important and early event in o carcinogen–induced lung tumorigenesis, and therapies that target mTOR could be effective in the tion or treatment of lung cancer. The biguanide metformin, which is widely prescribed for the ent of type II diabetes, might be a good candidate for lung cancer chemoprevention because it tes AM...
متن کاملTeaching an old drug new tricks: metformin as a targeted therapy for lung cancer.
Identifying novel drugs for treatment of lung cancer remains of utmost importance, and, in recent years, targeted therapies have been acknowledged as particularly attractive. Metformin, a commonly prescribed oral hypoglycemic agent, has known effects on the mammalian target of rapamycin pathway, ultimately resulting in downstream inhibition of cellular growth and proliferation. In a recent arti...
متن کاملMetformin and lung cancer
Metformin, a commonly used anti-diabetic drug has emerged as a potential anti-cancer drug. Over the last few years, a mass of epidemiologic, outcomes and preclinical data has emerged demonstratic the potential clinical relevance and the mechanistic basis of the anti-cancer activity of this well tolerated drug in lung cancer. This review article summarizes this evidence that supports the trial o...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2010
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-10-0055